STEP 1: 

Eat a lemon! (try not to pucker)

Go for the funniest pucker, biggest pucker, craziest pucker, best pet pucker, youngest pucker, most ridiculous pucker, etc. etc. etc. Have fun with it!



Challenge three family members/friends/colleagues/complete strangers to do the same.

Make sure you video Step 1 and Step 2 and the aftermath (that's the best part!)

STEP 3: 

Post your No Pucker Challenge video on social media

Please include the following hashtags: #nopuckerchallenge #curenpc


Donate towards a cure!

A Special Thank You


A huge thank you to our supporters who launched the No Pucker Challenge reaching millions of people to help find a cure for Niemann Pick Type C.  

We are blown away with gratitude.

With special thanks to some of our first No Pucker Challenge takers including:



Maria Menounos

Ben Higgins 

Shawn Johnson East

Andrew East

The Starbenders

Rachel Pally

Karla Souza

Nikki De Loach

ABC7 News

JJ Hale

Jared Haibon

Darsha Phillips

Monrovia Fire Department 

San Gabriel Fire Department 

Lehigh University Athletics 

Loyola Law School 

Tennis Serves Others Orange County 

KFI AM 640 and Jennifer Jones 


First Day Tampa Bay

Residence Inn by Marriott

River North

Common Space Brewery

Three Weavers Brewing

Fig Mountain Brewing 

Topa Topa Brewing

West Coast Trial Lawyers

New Mexico Military Academy


Swim Labs

and more!


Help us find a cure. 

Supporting research efforts together with


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©2017 by Hope For Marian, Los Angeles, CA